The character as many of us know him is largely a creation of Bryan Singer and FOX, with the comic version being a less significant evangelical extremism with no ties to Wolverine or the Weapon X program. Personally, I find the movie version to be one of the franchises greatest villains and hope to see some version of him in the future, but could also see Marvel choosing not to use anything Fox created in their retool.
Would you like to see the MCU utilize the character William Stryker in their version of the X-Men?