Strange and Christine could've been a thing, but sadly it never happened and I'm sad that she didn't much to do after the first movie or the 2nd movie, but he hangout with a variant of her instead of his. But with Clea I feel like we could a lot more and interesting friendship and then later relationship when we both see them again and see what their been doing with the many multiverse incursions to fix.
I know strange didn't get Christine because of Thanos and being gone for 5 years, she got married to someone else. But the new women in his life I think it's a lot better.